TB-500 is well known in research on tissue repair and is frequently discussed in the same breath as BPC-157. Below we explain what the peptide is, how it relates to its parent protein, and what investigators have studied so far.
Key points
- TB-500 is a synthetic version of an active fragment of Thymosin Beta-4 (TB4).
- TB4 occurs naturally in many tissues throughout the body.
- Pre-clinical work has examined tissue repair, angiogenesis, flexibility and cell motility.
- The evidence is early-stage and the compound is not approved for human use.
Where TB-500 comes from
Thymosin Beta-4 is a protein found across a wide range of the body’s tissues. TB-500 is a synthetic peptide based on an active fragment of that protein, rather than the full-length molecule. Researchers have studied it mainly in relation to tissue repair, tissue elasticity and the movement of cells.
What has been investigated?
Pre-clinical studies have explored TB-500 in connection with:
- tissue repair processes;
- angiogenesis, the formation of new blood vessels;
- tissue elasticity and flexibility.
It is often described as more “systemic” in character than peptides studied in relation to a specific region. As with much of this field, the research is at an early stage and TB-500 is not approved for use in humans.
Why it is often paired with BPC-157 in research
Both peptides turn up in recovery-related research, but the mechanisms investigated for each are different and are often described as complementary. That is why many research groups examine them side by side. Our BPC-157 vs TB-500 guide breaks down the differences, and our BPC-157 overview covers the other half of the pair.
Frequently asked questions
Are TB-500 and TB4 the same thing?
No. TB-500 is a synthetic fragment, or version, related to Thymosin Beta-4 — it is not the complete protein.
In what form is it supplied?
As a lyophilised powder, which is usually reconstituted in the laboratory with bacteriostatic water. For concentration calculations, see our peptide calculator.
Where are the product specifications?
Full details of the research material are on the TB-500 product page. For a broader primer, see our general guide to peptides.
Research use only
All Evil Peptides products are supplied strictly as reference materials for laboratory research. They are not medicines, are not intended for human or veterinary use, and nothing in this article should be read as medical advice or as a claim about effects in people.