Semax is among the better-known peptides in nootropic research, investigated for its possible relevance to cognition and neuroprotection. Below we explain what Semax is, where it originated and what laboratories have examined.
Key points
- Semax is a synthetic peptide derived from a fragment of the hormone ACTH.
- It does not retain ACTH’s classic hormonal activity.
- Research has focused on attention, memory, neuroprotection and BDNF.
- Most of the data is still early-stage.
What is Semax?
Semax is a laboratory-made peptide built on a fragment of adrenocorticotropic hormone (ACTH), but without the conventional hormonal action associated with ACTH itself. Like Selank, it emerged from Russian research and has been studied mainly in cognitive and neuroprotective settings.
What does the research examine?
Studies involving Semax have explored attention, memory and the protection of neural tissue. Researchers have also looked at its influence on factors such as BDNF (brain-derived neurotrophic factor), a protein associated with neural plasticity. Semax is one of the more extensively studied compounds in the nootropic field, yet much of the evidence remains preliminary.
Why is Semax studied alongside Selank?
Semax and Selank share a common research lineage and are sometimes examined together. The distinction usually drawn is that Semax has been investigated more in a cognitive context, whereas Selank has been investigated more in relation to emotional regulation.
Handling in the laboratory
Semax is supplied as a lyophilised powder and is reconstituted for laboratory use with bacteriostatic water. Our reconstitution calculator helps with concentration calculations.
Frequently asked questions
Is Semax a hormone?
No. Although it is based on a fragment of ACTH, it lacks that hormone’s classic hormonal activity.
Further reading
Specifications are available on the Semax research product page. For a broader introduction, read our guide to research peptides.
Research use only
This article is for general educational purposes and is not medical advice. All Evil Peptides products are research reference materials for laboratory use only. They are not medicines and are not for human or veterinary consumption.