Longevity science has put a small group of peptides and related molecules in the spotlight. The popular label, “anti-ageing peptides”, promises far more than the evidence supports, so here is what is genuinely under investigation.
Key points
- “Anti-ageing peptides” is a marketing phrase rather than a scientific category.
- GHK-Cu, NAD+ and MOTS-c are studied in relation to skin, cellular energy and mitochondrial function.
- Most research is early-stage; effects on human ageing are unproven.
What does the term actually describe?
The phrase usually refers to compounds examined in the context of age-related processes: skin and collagen turnover, cellular energy production and mitochondrial function. These are active fields of study, not evidence of a “fountain of youth”.
The molecules most often discussed
GHK-Cu
GHK-Cu is a naturally occurring copper-binding peptide. It has been studied in connection with skin, collagen and tissue remodelling, and its natural levels decline with age.
NAD+
NAD+ is a coenzyme at the heart of cellular energy metabolism. Its levels also fall with age, which is why it features in ageing research.
MOTS-c
MOTS-c is a short peptide encoded in mitochondrial DNA. It is investigated in the context of metabolism and longevity.
Keeping expectations realistic
Few fields attract as much sensationalism as ageing. Most work on these molecules is preliminary, early findings cannot simply be extrapolated to people, and any effect on human ageing remains unproven.
Frequently asked questions
Is NAD+ a peptide?
No. It is a coenzyme, but because it is studied in the same field it is usually grouped with peptides.
In what form are these compounds supplied for laboratory work?
As a lyophilised (freeze-dried) powder, reconstituted in the lab with a sterile diluent such as bacteriostatic water.
New to the subject? Our introduction to peptides covers the basics.
Research use only: this article is general and educational and is not medical advice. All products sold by Evil Peptides are intended solely for laboratory research and are not for human or veterinary use.